A macro-study refines the genetics behind the susceptibility of covid

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    A macro-study refines the genetics behind covid susceptibility

    An international study, with Spanish participation, has located 11 new positions in the chromosomes involved in susceptibility to infection by SARS-CoV-2 and in the clinical severity of covid-19.

    This macro-study analyzes 125,584 cases of infection in 25 countries, including Spain, to locate genetic determinants of the response to SARS-CoV-2, and their conclusions are fundamental to know the biological mechanisms of the disease, find effective treatments and protect potentially more vulnerable people.

    The results are published in the journal Nature and among the genes found it is worth highlighting certain genes encoding pulmonary surfactants which have a key role in lung function, reports the Higher Council for Scientific Research (CSIC) in a statement.

    Changes between people

    CSIC researcher Anna Planas, from the Barcelona Biomedical Research Institute (IIBB-CSIC), recalls that susceptibility and response to viral infections varies between people, as as the current SARS-COV-2 pandemic has shown

    “Environmental and social factors contribute to the risk of contracting the infection, while male sex, advanced age and the presence of other diseases contribute to the risk of developing severe covid-19,” he summarizes.

    However, he adds, genetic factors of the People also increase the probability of contracting the infection, of needing hospitalization or of developing critical covid-19.

    The results obtained in this study are the result from the COVID Host Genetic Initiative international consortium, which looks for common genetic variants in the populationthat can increase the risk of infection or of developing severe covid-19.

    To do this, this consortium carries out studies in thousands of patients. This work is an update with a larger number of patients of a study published by this consortium. in July 2021.

    Mega study

    It now presents a meta-analysis of genome-wide association studies (GWAS) of 125,584 cases of infection and more than 2.5 million controls collected in 25 countries throughout the world. ;s of 60 different studies.

    The CSIC has provided genetic data of 236 patients and 654 controls; The data analysis of this cohort has been led by Israel Fernández Cadenas, from the Sant Pau Hospital Research Institute (IIB Sant Pau).

    “In this new work, we expanded the map that we began last year and almost doubled the number of regions and chromosomes studied, going from 13 to 23,” details the researcher.

    Furthermore, They have included samples from all over the world, improving our knowledge of the biological processes that cause the severe symptoms of covid-19.

    Among these studies is the InmunGen-CoV2 project, included in the CSIC Global Health platform, and which brings together researchers from various CSIC institutes (the Barcelona Biomedical Research Institute, the Valencia Biomedicine Institute, the National Institute of Biotechnology and the Institute of Physics of Cantabria), the Research Institute of the Hospital de Sant Pau and the Idibaps-Hospital Clínic of Barcelona.

    It also has the collaboration of researchers from the Vall d'Hebron Hospital, the Mutua de Terrassa, the Central University Hospital of Asturias and the University Hospital of Valladolid.

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