Valery LEBOVKA, “FACTS”
For cancer use various methods of treatment. While scientists are increasingly turning to the antibodies — the main weapon of our immune system.
The most promising remedy for cancer are monoclonal antibodies. Obtaining such antibodies is one of the most important tasks of modern biotechnology.
Therefore, scientists around the world interested in the researchers from New Zealand, who said that they were able to create genetically modified goats, milk containing anti-cancer monoclonal antibodies. Article about it was published on the portal preprints and bioRxiv, writes National Geographic.
The researchers achieved that goats together with milk isolated immunoglobulin G to receptors of epidermal growth factors, similar to those contained in the drug called cetuximab. This medication is used to treat several types of cancer, in particular squamous cell carcinoma of the head and neck and metastatic colorectal.
The cost of the course cetuximab — about 13 thousand dollars. Scientists hope that their development will make cancer treatment more affordable.
“To produce cetuximab with animals is much more economical, because their mammary glands can produce large amounts of proteins”, explains head of the research group Goetz Laible.
It should be noted that the high cost of cetuximab not only due to the fact that this drug is laboratory method. Structure of immunoglobulins, constituent, very difficult. Therefore, they have to obtain from cell cultures under strictly controlled conditions, which, of course, leads to high production costs.
Genes encoding anti-cancer antibodies, inserted into the genome of goat cells. We used the same technology that was used to create the famous cloned sheep Dolly. Two lines of transgenic goats obtained as a result of such intervention, showed rather high concentrations of antibodies in milk — about 10 g/L.
In addition, immunoglobulins from goat’s milk, some characteristics were better than those contained in the commercial preparation. Thus, these antibodies are better associated with CD16 receptors on the surface of T-killer cells of the immune system, which leads to generation of antibody-dependent T-cell cytotoxicity and amplification of the immune response.
According to scientists, goats can be an excellent platform for large scale production of anticancer antibodies. Immunoglobulins can be easily allocated from milk and purified and genetically modified goats themselves feel normal and no different from ordinary animals.
Earlier, the “FACTS” wrote that the American was able to defeat cancer without drugs, though it is still without hair and part of the chest; but most importantly, stay alive.