Valery LEBOVKA, “FACTS”
In most cases, the main symptoms Covid-19 are fever, cough, shortness of breath. But if the disease is transferred hard, it can include acute renal failure, damage to internal organs and obscure blood clots.
At the same time, in recent years, more physicians have come to the conclusion that the virus is, in fact, may be aimed at the vessels and not the lungs, writes National Geographic.
Thus, research of unusual respiratory disease symptoms Frank Rosicka, an employee of the University hospital of Zurich started in April 2020. During the first autopsy died of coronavirus in the hospital, he found that tiny blood clots and dead cells clog the capillaries of the lungs, and inflammation has led to the expansion of blood vessels that supply the organs. His observations he published in the report for the Lancet, which noted that the virus was aimed at the blood vessels of his patients. “[Covid-19] is a vascular problem, says Rusiska. — Light is the main battlefield, but it is a disease of the blood vessels”.
Since the publication of the report came out several studies on this topic. An article published in the New England Journal of Medicine, showed that in the lungs of patients who died from Covid-19, nine times more microthrombi, than those who was sick with H1N1 (another respiratory disease), and the number of new blood vessels grew 2.7 times faster.
The process of formation of blood clots when infected Covid-19
A group of scientists from the Catholic University of Louvain in Belgium found that the endothelial cells (they line the inner surface of blood vessels) play a role in the development of severe forms Covid-19. Attacking them, the infection causes a change in blood pressure, blood clots and blood clotting disorders. This, in turn, triggers inflammation throughout the body and contributes to the development of acute respiratory distress syndrome (ARDS), are responsible for most deaths of patients.
The Belgian study may help to understand why mers is so dangerous for people with chronic diseases such as diabetes, obesity, or cardiovascular diseases. In such patients, the condition of the blood vessels have been broken, and SARS-CoV-2 — the pathogen behind Covid-19 — may bring out system restore is out of control. When SARS-CoV-2 enters the lungs, it grabs the cells that transfer oxygen to the blood and then invades the endothelial cells. Those, in turn, destroyed.
“It’s not a quiet death when a cell dies, says Neelam, Mangalmurti, doctors from the hospital of the University of Pennsylvaniawho was not involved in the new study. All its contents are oozing out”. Damage of cells can cause uncontrolled blood clotting, and the immune system, in turn, attracts additional factors, which leads to the formation of blood clots. Gradually, these processes begin in the body and block blood flow to vital organs. Finally, the inflammation begins, which can be fatal for patients.
The pathogen affects the appearance of cells that shows the latest study published in the journal Cell. They become long and branched, which contributes to the spread of infection.
“Clear visualization of the extensive branching filopodia again clarifies how understanding the biology of interaction between virus and host can illuminate possible points of intervention in disease,” says Nevan Krogan, Director of the Institute for quantitative biological Sciences at UCSF and a senior investigator in the Gladstone Institute.
Decision problems can be the use of existing and antivertignosic anti-inflammatory drugs and drugs targeting the activity of kinases (enzymes that are responsible for the spread of the virus). Researchers have identified dozens of suitable compounds and seven of them, primarily anti-tumor and inflammatory, demonstrated potent antiviral activity in laboratory experiments.
Earlier, the “FACTS” wrote that the Ministry of health of Ukraine has updated the treatment Protocol of patients with coronavirus, expanding its drug dexamethasone. This was at the briefing said the Minister of healthcare Maxim Stepanov. According to the Minister, the extension of national treatment Protocol from COVID-19 is based on the domestic experience in clinical trials and on the experience of other countries.