Invented a subcutaneous sensor to measure glucose levels more accurately

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  • The non-invasive and revolutionary technique is presented as an alternative for diabetics

  • The sensor is capable of tracking minute changes in dielectric permittivity due to to changes in blood sugar levels

Invented a subcutaneous sensor to measure glucose levels more precisely

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A study by the National Institute of Science and Technology in Ulsan (South Korea) has revealed a new way to measure blood sugar levels (BGL) without the need to draw blood. This is a revolutionary and non-invasive technique to measure blood glucose levels, using a sensor of Electromagnetic (EM) wave-based glucose tester that is inserted under the skin.

Their findings, published in the journal Scientific Reports, have garnered much attention as it eliminates the need for diabetes patients to constantly prick their fingers with a glucose meter.< /p>

In this study, the research team proposed an electromagnetic-based sensor that can be implanted subcutaneouslyand that it is capable of tracking minute changes in dielectric permittivity due to changes in BGLs. The proposed sensor, which occupies about one fifth of a cotton swab, can measure changes in glucose concentrations in interstitial fluid (ILF), the fluid that fills the spaces between the cells.

“This work is an effort to make an implantable electromagnetic-based sensor, which can be an alternative to the enzyme-based or optical glucose sensor. The proposed implantable sensor has not only overcome the drawbacks of current continuous glucose monitoring systems (CGMS), such as short lifespan, but has also< strong> improved the accuracy of blood glucose prediction,” the research team explained.

Diabetes can be diagnosed if fasting blood glucose levels are 126 mg/dL or higher. A normal fasting glucose test result is less than 100 mg/dL. One of the main goals of diabetes treatment is to maintain blood glucose levels within a certain range. More than 400 million people worldwide live with diabetes and continue to suffer from pricking their fingers several times a day to check their blood glucose levels.

Ongoing Research

Several alternative methods to the finger-stick method have been extensively studied for blood glucose testing, such as the enzyme-based or optical glucose sensor. However, they still have problems with longevity, portability, and accuracy.

In this study, the research team introduced semi-permanent, continuous blood glucose management with low maintenance cost and no pain caused by blood draws, allowing patients to enjoy a quality life through treatment and proper management of diabetes. This is expected to increase the use of CGMS, which is currently only 5%.

The research team also did some research. IV glucose tolerance test(IVGTT) and the oral glucose tolerance test (OGTT) with the sensor implanted in pigs and beagle in a controlled environment. Results from the initial in vivo proof-of-concept experiment showed a promising correlation between BGL and the sensor's frequency response, according to the research team.

“Our sensor The proposed system and system are in an early stage of development, however, the in vivo proof-of-concept results show a promising correlation between BGL and sensor frequency response. In fact, the sensor shows the ability to follow the BGL trend.For the actual implantation of the sensor we must take into account biocompatible packaging and foreign body reactions (FBR) for long-term applications. s, an improved sensor interface system is being developed,” the researchers conclude.