The finding opens the door to the investigation of new potential treatments
Cholesterol could also play a key role
A study by Edith Cowan University (Australia) has confirmed the Genetic link between intestinal disorders and Alzheimer's disease, which could lead to earlier detection and potential new treatments.< /p>
Alzheimer's destroys memory and the ability to think and is the most common form of dementia. It has no known curative treatments and is expected to affect more than 82 million people and cost $2 trillion by 2030.
Previous observational studies have suggested a association between Alzheimer's and disorders of the gastrointestinal tract, but what underlies these relationships was unclear, until now. This work, published in the scientific journal Communications Biology, has now provided new insights into these relationships by confirming a genetic link between Alzheimer's and multiple intestinal disorders.
The study analyzed Large genetic datasets from Alzheimer's and from several studies on intestinal disorders, each involving 400,000 people. The director of the research, Emmanuel Adewuyi, has stated that this is the first comprehensive evaluation of the genetic relationship between Alzheimer's and multiple intestinal disorders.< /p>
The team discovered that people with Alzheimer's and intestinal disorders have genes in common, which is important for many reasons. “The study provides new insight into the genetics underlying the observed coexistence of Alzheimer's and intestinal disorders. This improves our understanding of the causes of these conditions and identifies new targets for investigation< /strong>to potentially detect the disease earlier and develop new treatments for both types of conditions,” said Dr. Adewuyi.
Although the study does not conclude that intestinal disorders cause Alzheimer's or Vice versa, the results are enormously valuable.These results provide further evidence to support the concept of the “gut-brain” axis, a bidirectional link between the cognitive and emotional centers of the brain and normal functioning. intestines.
Is cholesterol the key?
When the researchers took a deeper look at shared genetics, they discovered other important links between Alzheimer's and intestinal disorders, including the role that may play. >cholesterol.
Abnormal cholesterol levels have been shown to be a risk for both Alzheimer's and intestinal disorders. “Study of the genetic and biological features common to Alzheimer's and these intestinal disorders suggests that lipid metabolism, the immune system, and cholesterol-lowering medications play a important role“, Adewuyi details.
Although the mechanisms common to both diseases must continue to be studied, there is evidence that high cholesterol can reach the central nervous systemand cause abnormal cholesterol metabolism in the brain.
“There is also evidence to suggest that abnormal blood lipids may be caused or worsened by intestinal bacteria ('H. pylori' ), supporting the potential role of abnormal lipids in Alzheimer's and intestinal disorders For example, elevated cholesterol in the brain has been linked to brain degeneration and subsequent cognitive decline “, wields Adewuyi.
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