Valery LEBOVKA, “FACTS”
If in later years people begins to forget recent events, the way home, do not know the family, losing the familiar skills, you may suspect Alzheimer’s disease. And, sadly, most patients with Alzheimer’s disease were women.
And it’s not that women live longer than men, according to the article in the journal Neurology, which is written according to the results of research conducted by scientists from the United States.
“About two-thirds of carriers of Alzheimer’s disease were women. Scientists previously explained this proportion the fact that women live longer than men. The results of our study indicate that changes in the brain can predict hormonal factors. That is, the onset of menopause can reliably predictthat in the brain in women can be changes associated with Alzheimer’s disease”, — said Lisa Mosconi, a neuroscientist from Cornell University (USA), one of the study’s authors writes TASS.
Scientists assume that the main symptom and a possible cause for development of Alzheimer’s disease is the accumulation within brain cells of a pathogenic protein , the so — called beta-amyloid. It represents fragments of the APP protein, which plays an important role in the formation of connections between neurons.
According to yet unknown reasons in the body of some people is broken recycling old molecules APP. The result in cells and brain tissues accumulate “trimming” of this protein and of them begin to form a self-propagating toxic tangles. They gradually kill neuronsthat eventually leads to dementia and death.
Having studied the health of 120 volunteers of both sexes, who had never complained of memory problems or cognitive impairment, Mosconi and her colleagues found another big risk factor that is associated with the occurrence of Alzheimer’s disease in older women.
Scholars interested in early signs of developing Alzheimer’s disease, including the decrease in the volume of white and gray matter of the brain, the rate of accumulation of beta-amyloid in the neurons, and a typical level of activity. Using this information, biologists have compared them with all known risk factors in order to understand which of them are most significant.
It turned out that most men who participated in the study, all three indicators were normal, in contrast to the female volunteers. On average they had 30% more amyloid plaques than males, and metabolic rate of cells was 22% below. In addition, the volume of gray and white matter they had 11% lower than men of the same age.
Comparing the results of the analyses of women, the researchers found that the accelerated accumulation of beta-amyloid and rapid reduction in brain volumes was primarily due to the fact, how much has changed in their hormonal balance after menopause. The stronger decreased production of hormones, the more pronounced were the changes in the brain of women, which was quite common for men.
This means that the fairer sex are more vulnerable to Alzheimer’s disease is not in the declining years of life, and in 45-50 years, when the level of estrogen and other sex hormones is reduced to a minimum. This feature of women, how do you think Mosconi and her colleagues, you need to consider when the diagnosis and treatment of these patients.
Earlier, the “FACTS” wrote that another factor affecting the brain of elderly people, may be overweight — in this case, the likelihood of developing dementia is higher by 30% or more. To such conclusion the group of researchers from University College London Professor Andrew steptow.