The bad news. The effectiveness of advanced anti-aging products varies by gender
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Researchers claim that the effect of anti-aging drug depends on sex.
Study on fruit flies shows how gender determines the response to the anti-aging drug rapamycin, writes Technology Org.
How a drug affects women and men can be drastically different. This concerns the most promising anti-aging drug to date, rapamycin, according to researchers from the Max Planck Institute for the Biology of Aging in Cologne and University College London.
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They argue that the drug can only prolong the life of female fertile flies, but not males. In addition, rapamycin only slowed down the development of age-related pathological changes in the intestines of females. Therefore, the researchers came to the conclusion that the biological sex is a decisive factor in the effectiveness of anti-aging agents.
The life expectancy of women is much higher than that of men. However, they are more likely to suffer from age-related diseases and adverse drug reactions.
“Our long-term goal is to ensure that men live as long as women, and women are as healthy as men in older age. But for this we need to understand where these differences come from,” explains one of the lead authors of the study, Yu-Xuan Lu.
The researchers gave the anti-aging drug rapamycin to male and female fruit flies to study its effects on different sexes. Rapamycin is a cell growth inhibitor and immune regulator commonly used in cancer therapy and after organ transplantation. Scientists have found that rapamycin prolongs lifespan and slows down the development of age-related intestinal pathologies in female flies, but not in males.
Except in flies, this effect was repeated in mice. Female mice showed increased autophagy activity after treatment with rapamycin.
According to Yu-Xuan Lou, female mice had a greater response to rapamycin in terms of lifespan extension than male mice, so this allowed us to uncover the underlying mechanism of these differences in the example of flies .
Linda Partridge, senior author of the study, adds that gender may be a factor in the effectiveness of anti-aging drugs, and understanding the processes that determine the response to a therapeutic drug will improve the development of personalized treatments.